Causes Gout - The role of uric acid

Gout is a metabolic disorder related to increased production or decreased excretion of uric acid in the body. We can say the direct cause of gout is caused uric acid, a byproduct generated by the breakdown of purines. In normal people, the amount of uric acid in the blood is maintained at a fixed 5mg% of men and 4 mg% in women, depending on age and change. To balance the daily uric acid, uric acid is excreted mainly in the kidney into the urine and feces, and partly through other avenues.

One reason, levels of purines in the body increases, our metabolism increases uric acid. When the body produces too much uric acid or the acid waste too little urine uric acid levels in the blood increased, uric acid metabolism increases urate salts leads to the deposition of urate crystals of salt sharp needles in the joints, cartilage, bone, held under the skin, causing inflammation and swelling and symptoms at the deposition location.

Causes of increased uric acid

Increased birth: disease Lesch - Nyhan: HGPT deficiency due to increased uric acid levels from small, the disease manifests in the body, nerve, kidney and joints. This disease is very rare and very severe.

Primary gout: a disease associated with genetic factors and atopic, these patients have the synthesis of endogenous purines increase cause hyperuricemia. This is also a major cause of disease.

Secondary gout: uric acid in the blood may increase secondary to the following reasons:

+ Due to consume foods containing purines (liver, heart, meat, fish, mushrooms, shrimp, crab), drink more alcohol. Actually this is only the agent has the disease rather than a direct cause.

+ Do in body enhancing endogenous purine degradation (destroying cells and organizations) related to hematological diseases such as polycythemia disease, may experience leucemie marrow, Hodgkin, accounting sarcoma, multiple myeloma bone , or by the use of drugs to kill cells treatment of melanoma.

+ Due to reduce uric acid by the kidneys: chronic nephritis, kidney failure makes the process of reducing uric acid excretion and retention disease.

The role of uric acid in arthritis

In gout , urate crystal deposition in monosodic synovial membrane will cause a series of reactions:

+ Activities Hageman factor in place thereby stimulating the inflammatory precursor Kininogen kallicreinogen become kallicrein kinin and inflammation in the synovium.

+ From the inflammatory response, leukocytes to focus, white blood cells and acts of urate crystals release of leukocyte enzyme (lysozim). These enzymes are also a very strong inflammatory agent.

+ Inflammation of the synovial membrane increases metabolism, lactic acid students in place and reduce the pH of the environment as they attempt more urate deposition and inflammation here to become a continuous closed loop inflammation lasts. Therefore, the fact that the two could gout: Can gout, acute inflammatory process going on in a short time and then terminate, or recurrence. Can chronic gout urate deposition process and prolonged, continuous expression of inflammatory will not stop.