18/12/14

The drug causes hyperuricemia

  Gout is a disorder of purine metabolism with the result hyperuricemia. There are many causes of hyperuricemia. Within the scope of this article, please refer to the cause may have cause hyperuricemia is used by some drugs decreased excretion of uric acid by the kidneys as aspirin, phenylbutazone prolonged low dose, the majority of drugs diuretics (spironolactone group minus) prolonged use; tuberculosis drug as ethambutol, pyrazinamide ...
Group diuretics:
Diuretics are indicated for the treatment of edema of heart failure, cirrhosis, chronic or acute renal failure, nephrotic syndrome ... be used alone or in combination with other antihypertensive drugs to treat hypertension pressure. Most of the group diuretic drugs, whether thiazide diuretic group; loop diuretic furosemide ... prolonged use can cause hyperuricemia. The diuretic reduces uric acid excretion by the kidneys, leading to increased levels of this substance in the blood.

These include some diuretics cause hyperuricemia as hydrochlorothiazide, thiazide diuretics and similar groups other thiazide (chorthalidone, metolazone); loop diuretic furosemide, bumetanide, ethacrynic acid; diuretic indapamide group; ... Only amiloride diuretic spironolactone group is not affecting uric acid excretion can be prolonged in patients with gout or hyperuricemia condition asymptomatic; while most of the other medications should be careful when using, especially if you have prolonged use.


Aspirin
Aspirin or acetylsalicylic acid (ASA) is a derivative of salicylic acid, of the group of non-steroidal anti-inflammatory drugs; has analgesic, antipyretic and anti-inflammatory. The drug also has anti-platelet aggregation, prolonged low doses can prevent heart attacks and forming clots in the blood vessels. In addition to the unwanted effects occur as gastrointestinal disorders: stomach upset, bloating, nausea ... Aspirin also has an effect on the process of elimination of uric acid, but depending on the dose: dose 1-2G / day or lower effective to reduce uric acid excretion by the kidneys leading to hyperuricemia. High dose of 2 g / day increased uric acid by the kidneys leading to reduced blood uric acid.

Photos uric acid deposition in joints.
However, high-dose aspirin should not be used as treatment for lowering uric acid in gout because it reduces the effects of other drugs that treat gout and increasing adverse effects on gastrointestinal. In case of gout patients to low-dose aspirin for the purpose prolonged anti-platelet aggregation caution, weigh the benefits and risks. If you can replace it with other drugs such as clopidogrel (plavix), dipyridamol (persantin, curantyl).
TB drugs:
Tuberculosis is now quite popular and have an increased risk of high society, especially when it is coordinated with the syndrome acquired immunodeficiency (AIDS). The anti-TB drug regimens, which generally have a combination of drugs such as streptomycin, rifampicin, isoniazid, ethambutol, pyrazinamide ... Among ethambutol and pyrazinamide drug on the two drugs can increase blood acid. These drugs should be avoided when there is an acute gout attack.
Group drugs vincristine, cisplatin ... is the drug used in the treatment of various malignancies such as Hodgkin's lymphoma and non-Hodgkin's malignant, Burkitt lymphoma, multiple myeloma bone disease ... immunosuppressive drug cyclosporin, cyclophosphamide is used to treat autoimmune disorders such as arthritis body, lupus erythematosus system, autoimmune hemolytic anemia, hemorrhage and thrombocytopenia idiopathic, inflammatory diseases such as Wegener's granulomatosis circuit, psoriatic severe ... The drug increases uric acid excretion by reducing uric acid in the urine and can cause increased cell death together.
Some drugs also cause hyperuricemia as phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) treatment effects of fever, pain and inflammation in the body. Ketoconazole is one of the first oral drug to prevent fungus. Isotretinoin is the cure acne by reducing the secretion and stimulates the sebaceous glands thereby reducing scarring.

Theophylline is a bronchodilator used in the treatment group xanthine bronchial asthma, in addition to diuretics. Pentamidin, an antibiotic used to treat or jiroveci pneumonia (common in patients with HIV / AIDS). Levodopa used to treat Parkinson's disease. Some recent studies showed that some patients with hypertension with beta blockers sympathetic timonol found hyperuricemia but not in patients with hypertension, the timolol no discernible effect uric acid in the kidneys ...
In a nutshell, with increased morbidity today, especially gout combination with other pathologies so a user can have multiple drugs at the same time, so we should be cautious in use of some medications can increase blood uric acid leads to the onset of the disease gout

0 comments:

Đăng nhận xét