Causes Gout

(Institute of gout) Gout is a metabolic disorder related to increased production or decreased excretion of uric acid in the body. We can say the direct cause of gout is caused deposition of sodium urate crystals of salt in the body's organs, such as in the joints, in cardiac, renal, ...

Of sodium urate crystal salt is the product of uric acid precipitate when conditions are favorable. Since m ot reason, levels of purines in the body increases, the process of converting them into uric acid. When the body produces too much uric acid or the acid waste too little urine uric acid levels in the blood increased, uric acid metabolism increases urate salts leads to the deposition of urate crystals of salt sharp needles in the joints, cartilage, bone, held under the skin, causing inflammation and swelling and symptoms at the deposition location.

Photos urate salt crystals under polarized microscope black background image: Institute of Gout

Causes of increased uric acid

Uric acid deposition in joints

 Increased birth: disease Lesch - Nyhan: HGPT deficiency due to increased uric acid levels from small, the disease manifests in the body, nerve, kidney and joints. This case is very rare and very severe.

Primary gout: a disease associated with genetic factors and atopic, these patients have the synthesis of endogenous purines increase cause hyperuricemia. This is also a major cause of disease.
Secondary gout: uric acid in the blood may increase secondary to the following reasons:
- Due to the consumption of foods containing purines (liver, heart, meat, fish, mushrooms, shrimp, crab), drink a lot of alcohol. Actually this is only the agent has the disease rather than a direct cause.

- Because the body enhancing endogenous purine degradation (destroying cells, organization) related to hematological diseases such as polycythemia disease, may experience leucemie marrow, Hodgkin, accounting sarcoma, multiple myeloma bone , or by the use of drugs to kill cells treatment of melanoma.

- Due to reduce uric acid by the kidneys: chronic nephritis, kidney failure makes the process of reducing uric acid excretion and retention disease.

 The role of uric acid in arthritis
In gout, urate crystal deposition in monosodic synovial membrane will cause a series of reactions:

- Activities Hageman factor in place thereby stimulating the inflammatory precursor Kininogen kallicreinogen become kallicrein kinin and inflammation in the synovium.

- Since inflammation, leukocytes to focus, white blood cells and acts of urate crystals release of leukocyte enzyme (lysozim). These enzymes are also a very strong inflammatory agent.

- Inflammation of the synovial membrane increases metabolism, lactic acid students in place and reduce the pH of the environment as they attempt more urate deposition and inflammation here to become a continuous closed loop inflammation lasts. Therefore, the fact that the two could gout: Body acute gout , inflammatory processes happening in a short time and then terminate, or recurrence. Can chronic gout urate deposition process and prolonged, continuous expression of inflammatory will not stop.